A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol

Yijin Wang,Chen Xu,Jiong Li,I-Ming Hsing,Mansun Chan

doi:10.1016/j.sse.2005.09.015

A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol

Yijin Wang, Chen Xu + Show 3 more

https://doi.org/10.1016/j.sse.2005.09.015

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Journal: Solid State Electronics	Publication Date: Nov 14, 2005
Citations: 8

Affiliation: Hong Kong University of Science and Technology, University of Hong Kong

#CMOS Active Pixel Image Sensor #Ordinary Light Source + Show 8 more

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Abstract

A DNA micro-array (DMA) for DNA detection is reported. The DMA combines a standard CMOS active pixel image sensor with a DNA detection protocol utilizing the binding of DNA targets and probes functionalized with gold nano-particles that can modify the opaqueness at the detection site. The DMA has been fabricated using a 0.5 μm CMOS process together with on-chip timing control and correlated double sampling. Experimental results show that the system can detect DNA samples with extremely low concentration down to 10 pM using ordinary light source.

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