Abstract
A closer look at the mysterious HSD17B13
Highlights
17-b hydroxysteroid dehydrogenase 13 (HSD17B13) belongs to a 15-member family that is involved in various metabolic processes, including steroid hormones, fatty acids, cholesterol, and bile acids (1)
The report by Ma et al has identified three fragments within the N-terminal 106 amino acids, which are required for HSD17B13 targeting to the normal destination; that is, lipid droplets: AA416 hydrophobic domain, AA22-28 PAT-like domain, and AA69-106 a-helix/b-sheet/a-helix structure
It was observed that the a-helix/b-sheet/a-helix structure may play a role in HSD17B13 proper folding in the endoplasmic reticulum (ER) and trafficking from ER to lipid droplet
Summary
17-b hydroxysteroid dehydrogenase 13 (HSD17B13) belongs to a 15-member family that is involved in various metabolic processes, including steroid hormones, fatty acids, cholesterol, and bile acids (1). Previous reports have shown that HSD17B13 is associated with lipid droplet (4, 6, 8, 16); it is unclear which peptide sequences are involved. The report by Ma et al has identified three fragments within the N-terminal 106 amino acids, which are required for HSD17B13 targeting to the normal destination; that is, lipid droplets: AA416 hydrophobic domain, AA22-28 PAT-like domain, and AA69-106 a-helix/b-sheet/a-helix structure.
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