A Closer Look at the eve Stripe 2 Enhancers of Drosophila and Themira

Justin Crocker,Albert Erives

doi:10.1371/journal.pgen.1000276

Abstract

A Closer Look at the eve Stripe 2 Enhancers of Drosophila and Themira

Highlights

Gene regulatory sequences have been investigated and/or proposed to be important targets of natural selection during animal evolution [1,2,3,4,5,6,7,8,9,10,11,12,13,14]
The internal functional organization of enhancers is important for understanding the mode and tempo of gene regulatory evolution as well as for deciphering and annotating genomic sequences
Including organized sites, because the position-weighted matrices were developed to Drosophila sequences, and because the Themira binding preferences may have diverged since their latest common ancestor, resulting in an artifactual phylogenetic decay of detection

Summary

Introduction

Gene regulatory sequences have been investigated and/or proposed to be important targets of natural selection during animal evolution [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. This latest study is used to make a central claim that a lack of sequence conservation between the eve stripe 2 enhancers of Drosophila melanogaster and Themira putris suggests that ‘‘complex animal regulatory sequences can tolerate nearly complete rearrangement of their transcription factor binding sites’’. These ordered blocks of homology encompass well-known activator and repressor binding sites.

Results

Conclusion