Abstract
ABSTRACT Aim Probable mechanism of pigmentation in oral lichen planus which is associated with anxiety disorder and its relation to gamma aminobutyric acid whose imbalance in brain occurs during stress and strain. Materials and methods A cross-sectional study comprising of 33 cases of clinically diagnosed oral lichen planus was conducted. Ethical clearance and informed consent was obtained. Detailed history was recorded and clinical examination was conducted. All patients were subjected to thorough routine blood, urine and stool examination for any systemic conditions. Clinical photographs and biopsies were obtained. The biopsy specimens were subjected to hematoxylin and eosin and periodic acid Schiff's reagent staining. Results Histopathological features of lichen planus include hyperkeratosis, liquefaction degeneration of stratum basale and subepithelial band of chronic inflammatory cells. Lichen planus is related to anxiety as predisposing factor. Conclusion Due to excitation of melanocytes lichen planus are seen with pigmentation. How to cite this article Anjum R, Singh J, Kudva S. A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus. World J Dent 2012;3(4):330-334.
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