Abstract
目的 探讨热性惊厥(FC)患儿血清脑型肌酸激酶同工酶(CK-BB)和血浆内皮素(ET)水平的变化及其与脑损伤程度的关系.方法 将2005年11月至2007年12月在我院小儿内科病房救治的60例FC患儿作为FC组,其中单纯型热性惊厥(SFC)组和复杂型热性惊厥(CFC)组各30例,健康儿童30例作为正常对照组,分别进行血清CK-BB和ET的测定,CK-BB采用比色法测定,ET采用放射免疫法测定.结果 SFC组CK-BB的浓度为(11.85±3.16)U/L、ET的浓度为(66.73±14.62)ng/L;正常对照组CK-BB的浓度为(8.34±3.49)U/L,ET的浓度为(55.75±8.14)ng/L;两组比较差异有显著性(P<0.01);CFC组CK-BB的浓度为(18.94±5.59)U/L、ET的浓度为(92.65±21.57)ng/L,与SFC组和正常对照组比较差异均有非常显著性(P<0.01);惊厥发作持续时间≥15 min的患儿CK-BB的浓度为(14.99±3.51)U/L、ET的浓度为(91.42±21.13)ng/L,惊厥发作持续时间<15 min的患儿CK-BB的浓度为(9.84±3.47)U/L,ET的浓度为(61.11±10.33)ng/L,两者比较差异有非常显著性(P<0.01).结论 血清中CK-BB和ET水平与脑损伤的程度密切相关,CK-BB和ET水平越高,脑损伤程度越严重.FC后CK-BB和ET的及时检测对判断脑损伤程度及预后有重要意义。
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