Serum levels of S100β protein in 90 children with febrile convulsion

Abstract

Objective To understand the brain damage caused by different types of febrile convulsion (FC) detecting the serum levels of S100 β protein in children with FC after the episodes of convulsion.Methods Ninety children with FC were selected as an experimental group,who were hospitalized into our hospital from October 1st,2012 to April 30th,2013.At the same period,sixty children with upper respiratory tract infection were chose as a control group.The serum level of S100β protein was detected by enzymelinked immunosorbent assay (ELISA).Results The levels of serum S100β protein were statistically higher in the children with complex FC and in the children who were younger than 15-month-old than in the control group(P ＜ 0.05).Conclusions The children with complex FC and in young age have high level of serum S100 β protein,indicating they have different degree brain damage.To prevent nervous system sequelae,the onset time of FC should be shortened,the frequency of FC should be lowered,and neuroprotectants should be administrated. Key words: Febrile convulsion;  S100β protein;  Brain damage