A clinical observation of applying mitomycin C in LASEK surgery to prevent the formation of subepithelial corneal haze in patients with high myopia

Abstract

Objective To observe the applying of mitomycin C in LASEK surgery to prevent the formation of subepithelial corneal haze in patients with high myopia.Methods Sixty patients ( 120 eyes) with high myopia were randomly performed LASEK on one eye,and they were performed 0.02％ mitomycin C treatment during LASEK on the other eye separately.Regular follow-up of 6 month was done to observe the haze formation.Results In the LASEK group,the rate of the haze of grade 0.5 was 58.33％,48.33％,40.00％ in 1 month,3 months and 6 months,that of grade 1 was 13.33％,8.33％,5.00％,that of grade 2 was 0,1.67％,1.67％,that of grade 3 and 4 was 0.In the LASEK + MMC group,the rate of the haze of grade 0.5 was 36.67％,26.67％,13.33％ in 1 mouths,3 months and 6 months respectively,that of grade 1 was 1.67％,1.67％,3.33％,that of grade 2,3 and 4 was 0.There was significant difference (P＜0.05) in the haze between the two groups.Conclusion The occurrence of the haze in the LASEK + MMCgroup is milder than that in the LASEK group. Key words: Laser subepithelial keratomileusis; Mitomycin C ; Haze