A Clinical Investigation on the Theragnostic Effect of MicroRNA Biomarkers for Survival Outcome in Cervical Cancer: A PRISMA-P Compliant Protocol for Systematic Review and Comprehensive Meta-Analysis.

Peter Shaw,Mogana Rajagopal,Ravishankar Ram Mani,Deepa Suresh,Chitraabaanu Paranjothy,Srivarshini Sankar,Ashok Kumar Balaraman,Gothandam Kodiveri Muthukaliannan,Madanmohan Gupta,Raghul Senthilnathan,Siddhartha Baxi,Rama Jayaraj,Sasikala Chinnappan,Ilamathi Ilangovan,Thangavel Muthusamy,Sunil Krishnan

doi:10.3390/genes13030463

Abstract

Background: The most often diagnosed malignancy in women worldwide is cancer of the cervix. It is also the most prevalent kind of gynecological cancer in women. This cancer originates in the opening of the cervix and spreads through sexual contact. Even though human papillomavirus (HPV) may not cause cancer immediately, it does develop over time as a result of the virus’s lengthy persistence to cause dysplastic changes overtime, particularly in high-risk kinds. The primary objective of this research is to see if miRNAs are dysregulated as a result of treatment resistance in cervical cancer (CC). The aim is to see if these microRNAs may be utilized as biomarkers for detecting chemoresistance in CC, particularly for clinical applications. Methods: The recommended protocol for comprehensive study and meta-analysis (PRISMA-P) standards will be utilized for the analysis and data interpretation. The bibliographic databases will be methodically searched using a combination of search keywords. Based on established inclusion and exclusion criteria, the acquired findings will be reviewed, and data retrieved from the selected scientific papers for systematic review. We will then construct a forest from the pooled Hazard ratio (HR) and 95% C.I. values, data obtained using the random-effects model. Discussion: The focus of this study is to identify the function of miRNAs as a chemoresistance regulator and determine if they have the potential scope to be considered as biomarkers for cervical cancer. Through this systematic review and meta-analysis, the goal is to collect, compare, and analyze the data pertaining to the role of miRNAs in cervical cancer, thereby, enabling us to understand the role they play in chemosensitivity.

Highlights

They elaborate on how the respective miRNA causes resistance or sensitivity and the mechanism involved with decrease or increase in the chemoresistance of a specific anti-cancer drug
The underlying notion notion of of this this study study is is to to figure figure out out if if miRNAs miRNAs play play aa crucial crucial role role as as aa chemoresistance regulator in and if they can be used as a marker for identification
Chemoresistance regulator in CC and if they can be used as a marker for identification

Summary

Introduction

This cancer develops in the cervical opening and spreads as a result of sexual contact. The most often diagnosed malignancy in women worldwide is cancer of the cervix It is the most prevalent kind of gynecological cancer in women. This cancer originates in the opening of the cervix and spreads through sexual contact. Even though human papillomavirus (HPV) may not cause cancer immediately, it does develop over time as a result of the virus’s lengthy persistence to cause dysplastic changes overtime, in high-risk kinds. Through this systematic review and meta-analysis, the goal is to collect, compare, and analyze the data pertaining to the role of miRNAs in cervical cancer, thereby, enabling us to understand the role they play in chemosensitivity

Objectives

Findings

Methods

Conclusion