A clinical analysis on pregnancy with systemic lupus erythematosus in 33 women

Abstract

Objective To investigate the clinical characteristics,treatment,and pregnancy outcomes in pregnant women with systemic lupus erythematosus(SLE).Methods The clinical data on 33 pregnant women with SLE were retrospectively reviewed to analyse the changes and outcomes of pregnancy,including 19 selective pregnancy(selective group)and 14 non-selective pregnancy(non-selective group).Results SLE aggravated in 9(47.4％)pregnant women in the selective group,which included 4 fetal loss(21.1％).SLE aggravated in 12(85.7％)pregnant women in non-selective group,which included 11 fetal loss(78.5％).Rate of pregnancy loss was higher in selective group than in non-selective group(P＜0.05).15 of the 33(45.45％)patients developed obstetrics complications and 12(36.3％)developed lupus nephritis.Conclusions Patients with SLE should be under instruction by obstetricians and rheumatologists for preparing pregnacy.Those women should get pregnant during remission of SLE.Fetal and maternal monitoring should be fstrenghtened and pregnancy should be terminated properly.Attention should be paid to puerperium care and contraception Key words: Pregnancy; Systemic lupus erythematosus; Lupus nephritis