A class of additive-accelerated means regression models for recurrent event data

Abstract

In this article, we propose a class of additive-accelerated means regression models for analyzing recurrent event data. The class includes the proportional means model, the additive rates model, the accelerated failure time model, the accelerated rates model and the additive-accelerated rate model as special cases. The new model offers great flexibility in formulating the effects of covariates on the mean functions of counting processes while leaving the stochastic structure completely unspecified. For the inference on the model parameters, estimating equation approaches are derived and asymptotic properties of the proposed estimators are established. In addition, a technique is provided for model checking. The finite-sample behavior of the proposed methods is examined through Monte Carlo simulation studies, and an application to a bladder cancer study is illustrated.