Abstract
Preventing wound infection and avoiding secondary damage to wounds during dressing changes represents a significant clinical challenge. Developing wound dressings that mitigate wound infections and facilitate peel-on-demand property may solve the problem. In this study, a temperature-responsive hydrogel with antimicrobial and on-demand peeling properties was proposed. Basing on the Schiff-base reaction, a gelatin/oxidized chondroitin sulfate (GelOCS@Ag) hydrogel loaded with silver nanoparticles was synthesized via the straightforward amalgamation of gelatin, chondroitin sulfate, and silver nanoparticles. The resultant hydrogel exhibited commendable tensile, recovery, and temperature-responsive properties, effectively reconciling the dichotomy between adhesion and reversible adhesion, and thereby achieving the desired effect of on-demand peeling. Specifically, the adhesion strength of the GelOCS@Ag hydrogel reached 12.7 kPa at body temperature, in stark contrast to a mere 1.2 kPa at 10℃, facilitating easy detachment from the wound surface. Furthermore, the hydrogel exhibited potent antimicrobial properties and demonstrated excellent cytocompatibility. The GelOCS@Ag hydrogel has promising applications within the realm of wound dressings.
Published Version
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