Abstract
Intracranial Hypertension (IH) is a known side effect of GH therapy [1], but has many other aetiologies. Turner syndrome patients have growth failure related to loss of the SHOX transcription factor and so respond to high dose GH therapy. Turner patients also have a high incidence of middle ear disease that can cause intracranial hypertension via mastoiditis and venous sinus thrombosis. IH has been reported in Turner syndrome with no predisposing cause.
Highlights
Intracranial Hypertension (IH) is a known side effect of GH therapy [1], but has many other aetiologies
Turner syndrome patients have growth failure related to loss of the SHOX transcription factor and so respond to high dose GH therapy
Turner patients have a high incidence of middle ear disease that can cause intracranial hypertension via mastoiditis and venous sinus thrombosis
Summary
A case series of intracranial hypertension in patients with Turner syndrome, with and without growth hormone therapy. Turner patients have a high incidence of middle ear disease that can cause intracranial hypertension via mastoiditis and venous sinus thrombosis. > 35 mmHg. MRV showed abnormal venous drainage and GH therapy was not started. MRV showed abnormal venous drainage and GH therapy was not started Case 3; CSF pressure 20 mmHg and MRV abnormal sagittal sinus flow. In both patients, GH was successfully restarted at low dose with slow upward titration. Aim To describe a case series of 4 patients with Turner syndrome who developed IH
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