Abstract
BackgroundTriple neural tube defects are rare. To the author’s knowledge, there are only four reported cases available in the literature up to date. Controversies exist with regards to the development of neural tube defects. We revisit the multisite closure theory and try to explain the mechanism of neural tube defects in our case.Case presentationWe report a case of one-month-old baby boy who presented to us with three distinct neural tube defects. He had occipital and cervical encephaloceles along with thoracolumbar myelomeningocele accompanied by syrinx and mild hydrocephalus. All the three defects were surgically corrected with good neurological outcome.ConclusionIn the multisite model of human neural tube closure, there are only two fusion sites and two neuropores unlike in mouse. This can explain the origin of open neural tube defects including anencephaly and myelomeningocele (as in our case) but cannot account for the development of encephalocele, which appears to be a post neurulation defect.
Highlights
ConclusionIn the multisite model of human neural tube closure, there are only two fusion sites and two neuropores unlike in mouse
In the multisite model of human neural tube closure, there are only two fusion sites and two neuropores unlike in mouse. This can explain the origin of open neural tube defects including anencephaly and myelomeningocele but cannot account for the development of encephalocele, which appears to be a post neurulation defect
Triple neural tube defect (NTD) is a rare entity with only four cases previously reported in the literature [1,2,3]
Summary
In the multisite model of human neural tube closure, there are only two fusion sites and two neuropores unlike in mouse.
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