Abstract
The aim of the current case study was to evaluate the possible role of noni juice in the improvement of Crohn’s disease symptoms. A 35-year-old male suffered from Crohn’s disease for more than 10 years. Treatment prior to consumption of noni juice involved multiple monthly adalimumab injections, which lowered C-Reactive Protein (CRP) levels to 1.2 mg/L, even though symptoms persisted. Six months after he began drinking noni juice, including one month of consuming a combination of noni juice and olive leaf extract, his symptoms improved and CRP decreased to 0.0 mg/L. These improvements accompanied gradual decreases in adalimumab injection frequency, followed by cessation altogether. Noni juice possesses anti-inflammatory properties that involve multiple mechanisms, including immunomodulation. Relevant experimental data are reviewed and discussed within the context of this case.
Highlights
Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract
It was found that within the previous three years that the subject’s C-Reactive Protein (CRP) levels had become elevated, which were reported to be as high as 12.0 mg/L
His overall energy level was low, disease symptoms had worsened and he lost more than 15 kg, dropping to a body weight of 49 kg
Summary
Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract. Historically, this condition was described as non-sepcific granuloma of the intestine and was likely first reported in 1806 as a case of “stricture and thickening of the ileum” (Taylor, 1949). The disease was initially described by a Polish surgeon, Antoni Leśniowski (Bartnik, 2003) and by an American gastroenterologist, Burrill Bernard Crohn, as regional ileitis (Crohn et al, 1952). Symptoms of this condition may include diarrhea, abdominal pain, fever, anemia, weight loss and right lower quantrant mass (Berkow and Fletcher, 1992). Antiobiotics may be required to treat infections in some cases, but aminosalicylates, glucocorticosteroids and immunomodulators are commonly used to control inflammation in patients with Crohn’s disease (Kozuch and Hanauer, 2008). Studies of the anti-inflammatory and immunomodulatory potential of noni juice are reviewed in light of this case
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