A Case Report of Spontaneous Regression of grade 3 Clear Cell Endometrial Cancer

Abstract

Spontaneous remission of cancer (SR) is a rare, defined as a complete or partial, temporary, or permanent disappearance of all or at least some relevant parameters of a soundly diagnosed malignant disease without any medical treatment or with treatment that is considered inadequate to produce the resulting regression. We present the case of a 43-year-old woman who initially received a diagnosis of high- grade squamous intraepithelial lesion (HSIL) on a Pap smear, further examination and MVA (Manual Vacuum Aspiration) curettage biopsy revealing poorly differentiated clear cell adenocarcinoma of the endometrium, stage 1a3 and subclinical hypothyroidism. The patient was prescribed thyroid tablet replacement but chose not to pursue any cancer treatment. Following two consecutive MVA curettage procedures, she returned for a hysteroscopic examination and the third MVA curettage biopsy, the histological report indicated the absence of any malignancy. Throughout the course of her illness, the patient underwent a total of ten sessions of MVA endometrial curettage and received thyroid replacement therapy for her subclinical hypothyroidism. Despite our initial reservations, we continue to provide care and support to her throughout whole course of this illness. We demonstrated that a patient's autonomy in refusing medical treatment is a fundamental ethical and legal principle in healthcare. Conclusion: We report the 8 cases of spontaneous remission (SR) in endometrial cancer. Given the infrequent occurrence of such cases, it is imperative to involve in a comprehensive and in-depth discussion.