Abstract
Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin, T-cell lymphoma, representing only 2-3% of all lymphoid neoplasm's in adults according to World Health Organization (WHO). CD30 antigen-positive, large neoplastic cells characterize ALCL. We present here a 46-year-old male with pulmonary ALCL previously diagnosed with Hodgkin disease. Microscopically, atypical bi-and multinucleated cells with frequent mitoses were present. The neoplastic cells were large and had clear cytoplasm, large vesicular nuclei, and prominent nucleoli. Immunophenotypic analysis revealed LCA, vimentin and CD30 positivity. ALK immunostaining was negative. Immunohistochemical profile was consistent with ALK negative ALCL. The progression of Hodgkin lymphoma to aggressive non-Hodgkin lymphoma (ALCL in this case) is well known entity. After the diagnosis was established, our patient immediately had been referred to the Department of Hematology in order to get appropriate chemotherapy, necessary in such cases.
Highlights
Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin, T-cell lymphoma, representing only - of all lymphoid neoplasm’s in adults according to World Health Organization (WHO) ( )
Activator of transcription proteins, all of which seem potentially important in cellular transformation ( - ). t(, ) is the most common mutation in ALK+ ALCL ( )
The patient has previously been diagnosed with Hodgkin lymphoma and has been treated by chemotherapy at the Department of Hematology
Summary
Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin, T-cell lymphoma, representing only - of all lymphoid neoplasm’s in adults according to World Health Organization (WHO) ( ). CD antigen-positive, large neoplastic cells characterize ALCL ( ). ALK ( p ), is a receptor tyrosine kinase gene, involved in chromosomal t ( , ) translocation that causes the anaplastic lymphoma kinase (ALK) gene on chromosome to fuse with the NPM gene on chromosome This leads to formation of chimeric genes encoding self associating, constitutively active ALK fusion proteins that activate a number of downstream effectors, including phospholipase C-gamma, phospho-inositol ’-kinase, RAS, and signal transducer. The lung variant of ALCL is a rare entity that usually presents with mediastinal lymphadenopathy. A -year-old male was admitted to the Department of Thoracic Surgery because of mediastinal lymph node enlargement and involvement of right lung. Computed tomography (CT) of chest (Figure ) and Chest X -ray (Figure ) showed nodular infiltrations of the lung, and multiple enlarged lymph nodes in the mediastinum.
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