Abstract
Paclitaxel takes effects as an antineoplastic agent by inter-fering with microtubules and then blocking cell growth. It has been used to treat patients with lung, ovarian, breast, head and neck cancer, and advanced forms of Kaposi's sarcoma. Along with its reputation as an effective chemo-therapeutic drug, paclitaxel has numerous adverse effects. Among them, cutaneous adverse effects of paclitaxel in-clude pruritis, bullous fixed eruption, onycholysis, and transient erythrodysesthesia. Only several cases of scleroderma-like lesions have been reported throughout the world, and in Korea, only one case of paclitaxel induced scleroderma has been reported in 2006. We report a case of paclitaxel induced scleroderma in an 83-year old woman with ovarian cancer. After administration of paclitaxel and cisplatin, the patient presented with edema in both bra-chial areas, Raynaud's phenomenon, and sclerotic skin lesions in both extremities.
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