Abstract
Background: Ovarian metastasis is rare in cases of early-stage uterine cervical cancer. For the patients with stage 1b cervical cancer, the incidences of ovarian metastasis were 0.22% of squamous cell carcinoma and 3.72% of adenocarcinoma. The safety of ovarian preservation is controversial for young women, although these women may find it important to preserve fertility. Case: A 36-year-old Japanese woman underwent a loop electrosurgical excision procedure for cervical adenosquamous carcinoma with invasion of 0.8 mm in depth and 1 mm in horizontal extent. She wished to preserve her fertility and was therefore followed up without additional treatments. Thirty months after the loop electrosurgical excision procedure, she had 10 cm-diameter ovarian tumors and underwent hysterectomy, bilateral salpingooophorectomy, appendectomy. This ovarian tumor was revealed to metastasis from cervical carcinoma. Conclusion: To our knowledge, this is first reported case of ovarian metastasis with microinvasive adenosquamous cell carcinoma. The pathological characteristics are important for prognosis: frequent small foci of invasion and high atypia.
Highlights
Ovarian metastasis rarely occurs in cases of early stage uterine cervical cancer
We report a case of an ovarian metastasis that occurred 30 months after primary treatment for microinvasive adenosquamous carcinoma of the uterine cervix
Ovarian preservation has been considered for young patients and, the preservation of fertility is an important issue for young women with uterine cervical carcinoma
Summary
Ovarian metastasis is rare in cases of early-stage uterine cervical cancer. The safety of ovarian preservation is controversial for young women, these women may find it important to preserve fertility. The tumor’s histological type, extension, and pattern of invasion should be considered, cases should not be overtreated. We suggest that the following pathological characteristics are important for prognosis: frequent small foci of invasion and high atypia
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