Abstract
Primary hemangiopericytoma of the breast is a rare disease, especially the malignant one is. Preoperative examinations of a 48-year-old woman had indicated an advanced breast cancer. According to the General Rule for Clinical and Pathological Record of Mammary Cancer, it was diagnosed as T4bN1bMO Stage IIIb. Radical mastectomy was carried out. The resected specimen revealed that yellowish and grayish white tumor was arising in the mammary gland, accompanied by hemorrhagic necrosis, and had not invaded the greater pectoral muscle. Histologically, it was poor in connective fibers; the tumor cells seemed to fill up between numerous vessels;and mitosis was frequently found. From these findings, she was diagnosed to have a malignant hemangiopericytoma which was keratin-negative and epitherial membrane antigen-negative. Furthermore, the diagnosis was immunologically confirmed, because factor 8 was not stained with the tumor cells but did with some area of the vascular endotherium. Electron microscopy also showed the characteristic features. In Japan, only few cases of primary hemangiopericytoma of the breast have been reported, particularly fewer cases of malignant hemangiopericytoma having been found.
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