Abstract
Description of the first documented case of imported hepatitis E, associated with geno- type 4 of HEV and introduced from southern France. Clinical, epidemio- logic and laboratory analysis of the imported case of disease of hepatitis E was carried out. Phylogenetic analysis of nucleotide sequences of HEV isolate, taken from the patient, was carried out. Epidemiologic analysis allowed to assume imported character of the detected case of HEV-infection. Comparative analysis ofnucleotide sequences of regions ofthe open reading frame 2 (300 nt) and open reading frame 1 (721 nt) of HEV genome, isolated from the patient, showed identity of this isolate with variants of genotype 4 HEV, isolated in France in 2009 - 2011 from patients with autochthonous hepatitis E. The results obtained confirm the case of import into Russia of genotype 4 HEV from south-eastern France (Corsica), where spread of this virus genotype is observed in recent years.
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