Abstract
Idiopathic hypereosinophilic syndrome (HES) is a disease characterized by persistent hypereosinophilia (>1.5×109/L) for more than 6 months in the absence of other causes of reactive eosinophilia. Patients with HES presenting with multiorgan thromboses are rare. Herein we report a 57-year-old man with HES who presented with deep venous thrombosis of the lower extremities, portal thrombosis, pulmonary embolism, and mesenteric venous thrombosis, which led to intestinal obstruction. Conflict of interest:None declared.
Highlights
Idiopathic hypereosinophilic syndromes (HESs) are rare disorders that comprise a heterogeneous group of diseases characterized by unexplained persistent, nonreactive overproduction of eosinophils (>1.5×109/L) persistent for more than 6 months
HES is a rare hematological disorder, and its diagnosis is set when patients have persistently elevated eosinophil counts of >1.5 × 109/L for more than 6 months and other causes of reactive eosinophilia have been excluded through histopathological evaluation and imaging studies for internal organ involvement
To the best of our knowledge, multiorgan thromboses, as a presentation of HES especially associated with intestinal obstruction, is rare and have only been reported by Kobayashi et al [6]
Summary
Idiopathic hypereosinophilic syndromes (HESs) are rare disorders that comprise a heterogeneous group of diseases characterized by unexplained persistent, nonreactive overproduction of eosinophils (>1.5×109/L) persistent for more than 6 months. Sui T, et al:A Case of Hypereosinophilic Syndrome Presenting with Multiorgan Thromboses Associated with Intestinal Obstruction presenting with deep venous thrombosis of the lower extremities, portal thrombosis, pulmonary embolism, and especially mesenteric venous thromboembolism, which led to intestinal obstruction. White blood cell count was high (23.9×109/L) with 66.5% eosinophils (15.9 ×109/L), hemoglobin of 141 g/L, and thrombocytopenia of 11×109/L.
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