A CASE OF HODGKIN LYMPHOMA PRESENTING AS NEPHROTIC SYNDROME

Abstract

Paraneoplastic glomerulopathy has been reported in patients with malignancy.In particular, the association of Nephrotic Syndrome (NS) with Hodgkins Lymphoma (HL) is rare and there are few reports in the literature. Minimal change nephropathy is the most frequently observed renal lesion whereas this association appears, either simultaneously or within several months of each other. Nephrotic changes as part of the paraneoplastic syndrome are rare in lymphoid malignancies. 1% of cases of Hodgkins Lymphoma cases may present with nephrotic syndrome. We are reporting a case which initially presented as nephrotic syndrome and later was diagnosed to have of Hodgkins Lymphoma and managed accordingly. This report presents the case of a 13-year-old male in whom the diagnosis of NS was established six months before the diagnosis of Hodgkin lymphoma. Once chemotherapy was initiated, proteinuria and the clinical manifestations of NS, mainly oedema, disappeared. Considering that the NS can be a paraneoplastic manifestation of Hodgkin lymphoma, the careful clinical evaluation becomes mandatory in any child with NS and persistent proteinuria despite appropriate treatment protocol. The prognosis of these patients is good, the treatment of Hodgkin disease causing the disappearance of proteinuria.