Abstract
Background: Isolated Central Nervous System (CNS) involvement in Granulomatosis with Polyangiitis (GPA) is rare. There are limited accounts of such a presentation in the literature. Case presentation: A 61-year-old gentleman presented with right upper limb and lower limb weakness, slurred speech and confusion following two instances of mechanical falls while at home. A cerebrovascular event was suspected. He underwent Computed Tomography (CT) brain and Magnetic Resonance Imaging (MRI) brain which demonstrated leptomeningeal thickening of left frontal region with vasogenic oedema. The differential diagnosis included malignancy, infection and contusion. He initially commenced on Dexamethasone 8 mg, Keppra 250 mg and a combination of Ceftriaxone, Linezolid, Metronidazole to treat vasogenic edema and possible infectious cerebritis, respectively. His vasculitis screen demonstrated a positive p-ANCA, positive for high titer PR3-ANCA. He was diagnosed with cerebral vasculitis secondary to GPA and commenced on immunosuppressant treatment.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call