Abstract
An 18-year-old girl, who presented manifestations of dwarfism and typical Cushing's syndrome as well as some features of virilization, was presented. Height-and weight-age of the patient were 10 and 121/2 years, respectively. In spite of an increased androgen as was indicated by presence of an enlarged clitoris and increased output of 17-KS, retardation of osseous development and epiphyseal fusion was disclosed in x-rays of bones. These findings are attrib-utable to excessive secretion of glucocorticoids overwhelming the effect of androgen. At the same time, however, the increase in serum alkaline phos-phatase level suggests the presence of an accelerated osteoblastic activity.The removal of the left adrenal, which was almost normal in appearance resulted in marked improvement of clinical and. laboratory findings such as lowered blood pressure, restoration of regular menstruation, disappearance of glucosuria, normal circulating eosinophil, disappearance of hypernatremia and return of urinary corticosteroids to normal.
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