Abstract
Introduction: We present a case of a 69 years old Bulgarian patient with a Triple Negative (TN) MBC. One year after the Breast-Conserving Surgery (BCS), adjuvant chemo- and radiotherapy she was diagnosed with metastases in the sigmoid colon, mesosigmoid, loco-regional lymph nodes and in the brain. Case report: The patient was initially diagnosed with locally advanced TNBC of the left breast in March 2021. She had undergone 6 courses of neoadjuvant chemotherapy and BCS with axillary lymph node dissection on 15.07.2021. The patient had received 4 courses of CarboTAx and whole breast radiation therapy postoperatively until December 2021. Eight months after that she was diagnosed with large bowel lesion in the sigmoid and a second small one in the mesosigmoid on the follow up PET/CT. She was admitted and had undergone laparoscopic left hemicolectomy. Due to signs of central system disorder (headache, impaired vision and vertigo) she was sent to additional examination with MRI (17.10.2022). Several heterogenous formations were found in the supratentorial space. Discussion: TNBC presents an aggressive subgroup, associated with worse prognosis and in about 30-40% of the cases early metastases and recurrence are observed. MBCs have poor response rates to cytotoxic chemotherapy compared to other types of BC. Conclusion: The presented case is here to show the unpredictable biological behaviour of this pathology regardless of the adequate treatment plan and careful follow up and to remind the physicians to be permanently aware of the numerous manifestations of the disease.
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