Abstract
This study focused on determining the markers of Macrophage migration inhibitor (MIF), as well as the N-telopeptides of type I bone collagen (NTX), and some other parameters (alkaline phosphatase (ALP), vitamin D (Vit D), calcium (Ca), phosphorus (P), and magnesium (Mg), and their correlation with other parameters in osteoporosis. One hundred ten subjects were involved in the current study. There were two groups of patients: group I (30) women with severe osteoporosis and group II (30) women with mild osteoporosis. For comparison, 50 apparently healthy individuals were included as a control. Serum levels of MIF, and NTX were significantly higher in groups I and II as compared to the control group, which indicate that these two parameters were related to disease. Moreover MIF, and NTX were organized in one cluster when applying cluster analysis test to all the studied groups. This indicates that in most of the studied samples the two parameters were related to each other as well as to osteoporosis. Magnesium showed a significant decrease in its level in both groups as compared to the control. On the other hand, alkaline phosphatase (ALP) showed a significant increase in its activity in both studied groups as compared to the control. Vitamin D level manifested significant difference between group I and group II, with a significant decrease in its level when comparing group II with the control group. The MIF, NTX was highly associated with osteoporosis patients, in addition to Mg and Vit-D. On the other hand, Ca and P levels did not alter in a significant way with osteoporosis which may be considered as a risk factor as long as they are organized in one cluster with MIF, NTX, Mg, and Vit D in all the studied patients. Both markers showed a clear cut-off value using the ROC curve in which the best cutoff value of NTX was 166.8 pg/ml, and the best cutoff value of MIF was 6.6 ng/ml according to ROC analysis.
Highlights
Osteoporosis is characterized by the WorldHealth Organization (WHO) as a progressive systemic skeletal disorder identified by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and fracture susceptibility
The results showed a significant difference between patient’s groups [severe osteoporosis, mild osteoporosis] and the control group
T-score % was significantly increased in women with the severe osteoporosis group when compared to the mild osteoporosis group and control group, and they were significantly increased with mild osteoporosis group when matched with healthy women
Summary
Osteoporosis is characterized by the WorldHealth Organization (WHO) as a progressive systemic skeletal disorder identified by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and fracture susceptibility. Several parameters play a critical role in bone metabolism such as the macrophage migration inhibitor (MIF). Multiple studies have shown that over-expression of MIF has occurred in different tumors, such as lung, colorectal, breast, and prostate. Overall, by regulating both cell proliferation and invasiveness, over-expression appears to play a large function in tumor growth 4,5. In addition to controlling inflammation, several lines of evidence suggest that MIF may be related to energy metabolism. It is reflected in adipose and liver metabolism 9 ,10. Other markers are involved in osteoporosis like N-telopeptides of type I bone collagen NTX
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