Abstract
Introduction: Trichotillomania (TTM) is a body-focused repetitive disorder linked to psychiatric comorbidities. Comprehensive studies mapping its associations with a range of conditions remain limited. This study examines TTM’s associations with psychiatric, neurodevelopmental, substance-related, reproductive, and social factors using a national database. Methods: We performed a case-control study using the All of Us Research Program database. TTM cases (n=40) were matched to controls (n=400) based on age, sex, and ethnicity. Multivariate logistic regression was used to examine associations with comorbidities and lifestyle factors, controlling for demographic variables. Results: TTM was significantly associated with OCD (OR 18.3), BPD (OR 15), anxiety disorders (OR 10.2), alcohol abuse (OR 6.13), depression (OR 5.89), and vitamin D deficiency (OR 4.2) (all p < 0.01). Other significant associations included fatigue, social anxiety, PTSD, ADHD, and difficulty running errands alone. Conclusion: Our findings highlight the strong association between TTM and a wide range of psychiatric and behavioral conditions, emphasizing the need for integrated treatment strategies addressing both psychiatric and physical aspects.
Published Version
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