Abstract
BackgroundAcute myocardial infarction (AMI) is considered an acute coronary syndrome (ACS), which is caused by the death of myocardial cells after prolonged ischemia, and there is a high risk of sudden death during AMI. Therefore, the purpose of this study is to explore the relationship between thrombin activatable fibrinolysis inhibitor (TAFI) and AMI and provide evidence for their association and potentially the prevention of AMI.MethodsThere were 228 subjects included in this retrospective study, which included 78 AMI patients and 150 controls. The immune turbidimetry was used to measure TAFI concentration in the serum. Mann–Whitney U test was used to compare serum TAFI levels. The logistic regression analysis was used to construct a model of influencing factors of AMI. The dose-response relationship between serum TAFI level and AMI was explored by using the restricted cubic spline (RCS) functions combined with logistic regression analysis.ResultsThe serum TAFI levels of the AMI group were higher than the control group’s (P = 0.003). The risk of AMI in the high-TAFI level group was 2.24 times higher than the low-TAFI level group (P = 0.007) and it was 2.74 times higher after adjustment of other risk factors (P = 0.025). According to the dose-response curve, the risk of AMI increased significantly with an increase of serum TAFI concentration (P = 0.0387).ConclusionAcute myocardial infarction patients had higher serum TAFI levels, and TAFI was an independent risk factor for AMI patients. Serum TAFI levels demonstrated a dose- dependent response to the risk of AMI. Our study provides evidence that TAFI could be used for risk stratification of AMI patients.
Highlights
Acute myocardial infarction (AMI) is considered an acute coronary syndrome (ACS), which is caused by the death of myocardial cells after prolonged ischemia, and there is a high risk of sudden death during AMI
Inclusion criteria were as follows: the hospital confirmed the diagnosis of acute myocardial infarction patients and the time of diagnosis was between April 2018 to September 2019
A total of 78 AMI cases were selected in this study, and 150 controls were matched to the cases in sex and age by the method of propensity score matching (PSM)
Summary
Acute myocardial infarction (AMI) is considered an acute coronary syndrome (ACS), which is caused by the death of myocardial cells after prolonged ischemia, and there is a high risk of sudden death during AMI. Coronary heart disease is a major cause of death worldwide and the burden of AMI remains high despite optimal therapies [1]. In China, the mortality rate of AMI is continued on the rise from 2002 to 2016. Since 2005, the mortality rate of AMI has shown a sharp upward trend, especially in rural areas. In 2016, the mortality rate of AMI was 58.69 per 100,000 in metropolitan areas and 74.72 per 100,000 in rural areas [3]. The increasing social and economic burden of AMI has become an important public health problem, which needs to be addressed and prevented urgently
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