Convalescent plasma levels of TAFI activation peptide predict death and recurrent vascular events in ischemic stroke survivors

Abstract

[11], corresponding to 67–133%.Among the patients were 24 women with FXIII-A levels of< 70% (minimum: 52.4%). Whether these low levels wereattributabletoconsumptionorgeneticinfluenceswasnotfurtherstudied, and this might represent a limitation of our study.However, among the controls were 22 women with FXIII-Alevelsof< 70%(minimum:51.9%).Wethereforeconcludethatthis mild FXIII-A deficiency that we observed in some patientsandcontrolsisprobablynotrelatedtopregnancyloss.For the first time, we have compared FXIII-A and FXIII-Bplasma levels between women with unexplained recurrentpregnancy loss and controls without a history of miscarriageand with at least one successful pregnancy. Our results suggestthat recurrent pregnancy loss in the general population is notassociated with reduced FXIII plasma levels. Whether locallyreduced FXIII-A levels or impaired FXIII function in theplacenta may contribute to an increased risk of abortionremains to be investigated.Disclosure of Conflict of InterestsThe authors state that they have no conflict of interest.References