Abstract
We wish to report the observation of Watson-Crick base pairing between deoxyguanosine-5′-monophosphate (dGMP) and deoxycytidine-5′-monophosphate (dCMP), and the nature of the interaction of streptozotocin, an anticancer agent, with these mononucleotides, all in aqueous solution. Fourier transform carbon-13 ( 13C) nuclear magnetic resonance (nmr) relaxation time (T 1) measurements provided the evidence for complex formation. The dCMP 13C relaxation times are far more sensitive to the presence of dGMP rather than the antibiotic, whereas dGMP interacts strongly with both dCMP and streptozotocin. A description of these complexes and a correlation of these results with the observed clinical behavior of streptozotocin will be given.
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