Abstract
This work reviews the new isolated cembranoid derivatives from species of the genera Sarcophyton, Sinularia, and Lobophytum as well as their biological properties, during 2016–2018. The compilation permitted to conclude that much more new cembranoid diterpenes were found in the soft corals of the genus Sarcophyton than in those belonging to the genera Lobophytum or Sinularia. Beyond the chemical composition, the biological properties were also reviewed, namely anti-microbial against several Gram-positive and Gram-negative bacteria and fungi, anti-inflammatory and anti-tumoral against several types of cancer cells. In spite of the biological activities detected in almost all samples, there is a remarkable diversity in the results which may be attributed to the chemical variability that needs to be deepened in order to develop new molecules with potential application in medicine.
Highlights
The cembrane skeleton is isoprenoid and consists of a fourteen-membered carbocyclic ring with an isopropyl residue at position 1 and three methyl groups at positions 4, 8, and 12 (Figure 1).The basic structure of this diterpene usually presents cyclic ether, lactone, or furan moieties around the macrocyclic ring
Sinularin (143) was the best among the compounds isolated by the authors, displaying inhibition percentages higher than 80%, at 10 μM, significantly higher when compared to the new cembranoid diterpenes [sinulaflexiolides L-O (151–154) and ent-sinuflexibilin D
Wang et al [39] assayed the antifouling activity on the larvae of the bryozoan Bugula neritina and the barnacle Balanus albicostatus of all the cembranoid diterpenes isolated from S. flexibilis
Summary
ISBST, BVBGR-LR11ES31, Biotechpole Sidi Thabet, Ariana 2020, Tunisia. Received: 23 October 2018; Accepted: 10 January 2019; Published: 21 February 2019
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
