Abstract
Scientists everywhere are struggling to keep up with the latest published research studies, data pouring out of laboratories--those down the hall and across the world--as well as the vital content of numerous genomics and proteomics databases. A further problem facing researchers is the need to find, and assimilate complex research findings, biological pathways, protein structure resources, and genomics information. These problems are especially pressing for Alzheimer's Disease (AD) researchers where the critical findings may come from bench research, clinical trials or from seemingly unrelated animal research studies. The goal of the present work is to develop time-saving tools that break this bottleneck for research and discovery. Telemakus, a knowledge base creation system, is being utilized to develop a knowledge resource to support research on biomarkers in AD. Extracted research findings with links to the full-text data tables and figures and relevant genomics information are displayed in a consistent format that promotes rapid literature review an drilling down for more specific information. Further an interactive visualization interface provides graphical displays of research inter-relationships from documents across a domain allowing the user to review previously reported research connections and, develop hypotheses for future research. With innovative approach to presentation of research findings the Telemakus knowledge base system offers scientists new strategies to support knowledge discovery in the biomarkers and AD research domain.
Published Version
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