Abstract
Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (n = 10) and UNCD-coated (n = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, p > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants.
Highlights
Introduction conditions of the Creative CommonsPure titanium (Ti) and its alloys are widely used to manufacture dental and orthopedic implants, among other medical applications, given their appropriate mechanical properties and biocompatibility [1,2]
ultrananocrystalline diamond (UNCD) films grown on a substrate surface without the W layer exhibited a surface roughness of about 20 nm rms, while UNCD films grown on a 100 nm thick W layer showed a surface roughness of about 6.3 nm rms
The potential toxicity and biological risks associated with ions/particles released as a result of biotribocorrosion of metallic implants is a public health concern that afresultfects of biotribocorrosion metallic implants is awhether public health concern that since patients carrying aof metallic medical implant, orthopedic or dental, these affectsprostheses patients must carrying a metallic medical implant, whether orthopedic or dental, since remain inside the body over long periods of time, even decades [6,14,57,58]
Summary
Pure titanium (Ti) and its alloys are widely used to manufacture dental and orthopedic implants, among other medical applications, given their appropriate mechanical properties and biocompatibility [1,2]. Osseointegratable Ti dental implants have revolutionized clinical. Nanomaterials 2022, 12, 782 dental practice and have shown a high rate of success [3,4]. Some technical and/or biological complications associated with Ti dental implants can occur [5,6]. No metal or metal alloy is completely inert in vivo [7]. One of the possible causes of failure of a Ti implant after initial success is biotribocorrosion, which is the combined effect of mechanical, biochemical, and electrochemical factors in a biological environment [8–10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
