Abstract
Tartrazine a colorant is being used most commonly as food colorant in confectioneries, drugs and cosmetics. The present study was designed and performed to evaluate the toxic effect of Tartrazine, a widely used azo dye on Swiss Albino Mice. Experimental animals were treated with tested dye at dose levels 100mg/kg/b.w. and 200mg/kg/b.w. alongwith normal diet. Present study revealed a highly noticeable increase in body weight gain of mice at both dose levels (11.18 -16.14%) as compared to control group. A significant variation in the average weight of kidney, liver, and testes were decrease in both doses as compared to control group of mice. Organ weight and Acid Phosphatase, Alkaline Phosphatase, SGOT, SGPT, were significantly increased in both Tartrazine consumed experimental groups. From the present study it is concluded that Tartrazine adversely alters biochemical parameters in Tartrazine fed mice. The outcome of study will help us to make a decision in using Tartrazine as food dye.
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