A Biochemical Analysis beyond the Muscle Contraction and its Relation with Isaac Syndrome

Neto Valdemir Aquino De Freitas

doi:10.23937/2643-4571/1710028

Abstract

A Biochemical Analysis beyond the Muscle Contraction and its Relation with Isaac Syndrome

Highlights

The muscle contraction process starts on the Na+/ K+ pump during a nervous impulse
Through the action potential process, the impulse is able to follow the signal to a motor neuron, consuming energy since the ATPase hydrolyses the Adenosine Triphosphate (ATP) into Adenosine Diphosphate (ADP) + Inorganic Phosphate (Pi), releasing energy to restore the concentration of Na+ and K+ against the concentration gradient by active transport
There are many receptors of Acetylcholine, called Nicotinic Acetylcholine receptors due its affinity with nicotine. In this way, when the Acetylcholine is released to muscle cells, it binds with cholinergic receptors that activate the ryanodine receptors, which are Ca2+ channels, and the Ca2+ ions are released by the sarcoplasmic reticulum, a modified endoplasmic reticulum which can afford the amount of Ca2+ ions to the muscle cell [3]

Summary

Introduction

A nervous impulse comes from the nervous system and goes to a motor neuron through the action potential. The action potential consists in wave of positive charges that induces the open of the voltage-gated Na+ channels, the Na+ ions, which stay in high concentration outside the cellular membrane, flow through passive diffusion from outside to inside the cell, following the concentration gradient and the depolarization of the sarcolemma, the cell membrane of muscle cells, causes the slightly positive charge inside the cell. Through the action potential process, the impulse is able to follow the signal to a motor neuron, consuming energy since the ATPase hydrolyses the ATP into ADP + Pi, releasing energy to restore the concentration of Na+ and K+ against the concentration gradient by active transport. In muscle cells, that action potential is called end-plate potential

Results

Discussion

Conclusion