Abstract
This chapter reviews metal-promoted asymmetric CC, CN, and CO bond formations and their applications to the synthesis of active pharmaceutical ingredients (APIs). Both chemocatalytic and stoichiometric metal-promoted asymmetric reactions are covered in this review. The review discusses only those reactions in which a new CC, CN, or CO bond is formed. Reactions that do not involve new CC, CN, and CO bond formations such as asymmetric hydrogenation, metal-hydride reduction, epoxidation, hydroxylation, and enzymatic reactions are covered by other chapters. Although the target APIs are presented, the discussions focus on the asymmetric CC, CN, and CO bond formation step. Where possible and available, the reaction conditions, yields, and diastereo- and enantioselectivity are included. Although most of the reactions reviewed in this chapter come from process development, some good examples from discovery chemistry labs and the fine chemical industry are presented. Related asymmetric syntheses of APIs from academia and nonmetal promoted reactions, such as acid-catalyzed and thermo-asymmetric reactions are provided as references.
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