937 SPERMATOGENESIS IN THE TESTICULAR PARENCHYMA IPSILATERAL TO GERM CELL TUMORS

Abstract

You have accessJournal of UrologyPenis/Testis/Urethra: Benign & Malignant Disease (III)1 Apr 2013937 SPERMATOGENESIS IN THE TESTICULAR PARENCHYMA IPSILATERAL TO GERM CELL TUMORS Samuel Juncal, Carolina Kosako, Verena Juncal, Tulio Graziottin, and Claudio Telöken Samuel JuncalSamuel Juncal Porto Alegre, Brazil More articles by this author , Carolina KosakoCarolina Kosako Porto Alegre, Brazil More articles by this author , Verena JuncalVerena Juncal Porto Alegre, Brazil More articles by this author , Tulio GraziottinTulio Graziottin Porto Alegre, Brazil More articles by this author , and Claudio TelökenClaudio Telöken Porto Alegre, Brazil More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.516AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Introduction: Testicular cancer is the most common malignancy in young men at the peak of their reproductive potential. Due to the high cure rates in patients with testicular tumors, there has been an increasing clinical importance towards fertility?s protection. However, the act of sperm collecting with masturbation might be a huge issue for young adolescents and certain religions. The aim of this study is to assess the spermatogenesis in the testicular parenchyma ipsilateral to germ cell tumors in patients who underwent radical orchiectomy and estimate the feasibility of sperm retrieval synchronously during radical orchiectomy. METHODS The archived histological specimens of 54 patients who had undergone radical orchiectomy for primary testicular cancer between 2002 and 2011 were reviewed. The area of normal testicular parenchyma was examined to evaluate spermatogenesis using the modified Johnsen score. A minimum of 10 and maximum of 20 seminiferous tubules were scored per case. RESULTS The predominant histological pattern was hypospermatogenesis in 24% of the cases. Mature spermatozoa was identified in 35% of the testicular sections. In an univariate analysis, LDH, tumor volume, tumor staging and nodal metastatic disease were all inversely related to the probability of identifying mature spermatozoa in the testis (p<0.001, p<0.001, p=0.01 and p=0.002, respectively) Spermatogenesis in the parenchyma ipsilateral to seminoma tumor compared to nonseminoma tumor had a lower Johnsen score (p<0.0001). In a multivariate analysis, only tumor volume and nodal metastasis disease independently predicted the Johnsen score (p=0.004 and p=0.003, respectively). CONCLUSIONS A 35% probability of recovering spermatozoa ipsilateral to the germ cell tumors was found in archived histological specimens. Sperm retrieval at the time of radical orchiectomy is a feasible fertility option for patients with testicular cancer in which age and religion might be limiting factors for sperm collecting with masturbation. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e386 Peer Review Report Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samuel Juncal Porto Alegre, Brazil More articles by this author Carolina Kosako Porto Alegre, Brazil More articles by this author Verena Juncal Porto Alegre, Brazil More articles by this author Tulio Graziottin Porto Alegre, Brazil More articles by this author Claudio Telöken Porto Alegre, Brazil More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...