Abstract
SUMMARY The effect of the a,-adrenoceptor agonist, clonidine, on plasma growth hormone (GH), plasma 3methoxy-4-hydroxyphenylethylenegylcol (MBPG), blood pressure and sedation were studied in 16 menopausal subjects before and 6 wk after a lOO-mg implant of estradiol. The specific binding of tritiated yohimbine to intact platelets also was studied. Estradiol implants increased basal GH output and reduced baseline MBPG and sedation scores. However, none of the subsequent responses to clonidine were altered. Platelet yohimbine binding also was unchanged following the implant Both observer- and self-rating scales showed a marked reduction in anxiety and depression scores. The results suggest that estradiol may alter some indices of noradrenergic function, but that the mechanism does not involve alterations in cqadrenoceptor sensitivity.
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