Abstract
The 91st Annual Meeting of the American Association for Cancer Research (AACR) was held at the Moscone Convention Center in San Francisco, California, USA, April 1-5, 2000. The comprehensive and multidisciplinary nature of the AACR meeting was conveyed through a collection of concurrent symposia, minisymposia and poster sessions. These standard meeting forums were further supplemented by additional educational workshops, interactive 'meet-the-expert' sessions at the beginning of each day and panel discussions approaching more general interest topics, such as the relationship of media, science and consumers. Although it was generally impossible to attend all of the sessions on a particular topic, many topics were repeated in different formats throughout the meeting to allow for attendees to get a reasonable sampling of the current trends in each field. A number of scientists were honoured at the meeting for their outstanding contributions to cancer research. Charles Sherr (St Jude's Children's Research Hospital, Memphis, TN, USA) was awarded the Pezcoller International Cancer Research Award for his work on the mechanisms of cell growth control and neoplastic transformation. The Bruce F Cain Memorial Award was given to Axel Ullrich (Max-Planck Institute for Biochemistry, Martinsried, Germany) who has successfully translated his pioneering work on tyrosine kinase receptors, such as HER2/neu, into actual treatment strategies. Edison T Liu (National Cancer Institute, Bethesda, MD, USA) was also recognized for his work in establishing a correlation between HER2/neu overexpression and those breast cancers that have an unfavourable prognosis and high probability of responding to doxorubicin therapy. Finally, the prestigious GHA Clowes Memorial Award was presented to Elizabeth Blackburn (University of California, San Francisco, CA, USA) for her pioneering work in the discovery of telomerase and its potential role in cancer. Herein we outline a few of the many provocative studies discussed at the meeting. Although some of the topics discussed below are specific to the breast, others addressing global mechanisms of tumour progression are also considered because they may be appropriate paradigms for understanding and treating breast cancer in the future.
Highlights
The 91st Annual Meeting of the American Association for Cancer Research (AACR) was held at the Moscone Convention Center in San Francisco, California, USA, April 1–5, 2000
The comprehensive and multidisciplinary nature of the AACR meeting was conveyed through a collection of concurrent symposia, minisymposia and poster sessions
These standard meeting forums were further supplemented by additional educational workshops, interactive ‘meet-the-expert’ sessions at the beginning of each day and panel discussions approaching more general interest topics, such as the relationship of media, science and consumers
Summary
The 91st Annual Meeting of the American Association for Cancer Research (AACR) was held at the Moscone Convention Center in San Francisco, California, USA, April 1–5, 2000. In three related studies from the laboratory of Satyabrata Nandi (University of California, Berkeley, CA, USA), short-term hormone treatment appeared to be effective in mammary cancer prevention in rodents, which may be due to alterations in mammary epithelial cell signalling pathways resulting in a reduced proliferative response during carcinogenesis.
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