Abstract
910 A systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men
Highlights
Lower urinary tract symptoms (LUTS) in men are categorized into storage symptoms, voiding symptoms, and postmicturition symptoms [1,2]
Context: family studies have shown that male lower urinary tract symptoms (LUTS) are highly heritable, no systematic review exists of genetic polymorphisms tested for association with LUTS
We found consistent evidence of a reduced risk of LUTS associated with the common rs731236 variant of the vitamin D receptor gene in our meta-analyses
Summary
Lower urinary tract symptoms (LUTS) in men are categorized into storage symptoms (increased daytime urinary frequency, nocturia, urgency, and incontinence), voiding symptoms (slow stream, splitting or spraying, intermittent stream, hesitancy, straining, and terminal dribble), and postmicturition symptoms (feeling of incomplete emptying and postmicturition dribble) [1,2]. In a further population-based study of 3446 elderly male twins, heritability of moderate to severe LUTS (again assessed using the AUA-SI) was estimated at 72% [14]. Many of the studies available for this review aimed primarily to explore the molecular genetics of prostate cancer rather than LUTS, but they included men with and without LUTS as separate subgroups of controls It remains unclear whether LUTS or BPH might be risk factors for prostate cancer. Evidence of a consequent increase in high-risk cancers or prostate cancer mortality is mixed Those studies that have suggested a positive association may be unable to exclude detection bias and unmeasured confounding from shared environmental or genetic risk factors. The aim of this systematic review was to assess which candidate polymorphisms and/or candidate genes had been tested for an association with LUTS in men, and to assess the strength, consistency, and potential for bias among pooled associations
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