Abstract
Background: Because red blood cell distribution width (RDW) predicted cardiovascular disease (CVD) mortality, we evaluated the association between RDW and CVD risk factors in hypertensive subjects. Subjects and methods: From 2004 through 2007, 1,040 atomic bomb survivors (405 male) underwent health examination in Nagasaki, Japan. We classified subjects as having hypertension, diabetes mellitus (DM), hyperlipidemia (HLP), metabolic syndrome (MetS), or chronic kidney disease (CKD). We evaluated the association of RDW with CVD risk factors (relating to anthropometric indexes, and lipid and glucose metabolism), estimated glomerular filtration rate (eGFR), pulse wave velocity (PWV) and hematological measurements and compared RDW between controls and hypertensive, DM, HLP, Mets and CKD subjects, respectively. We also compared CVD risk factors, eGFR, PWV, and hematological measurements between hypertensive subjects and controls. Results: RDW were associated positively (P < 0.05) with age, HDL-cholesterol and adiponectin, but negatively (P < 0.05) with waist circumference, BMI, LDL-cholesterol, triglycerides, HOMA-IR, hemoglobin and hematocrit. Hypertensive subjects had deteriorated values of anthropometric indexes, and lipid and glucose metabolism compared to controls. In addition, hypertensive subjects had lower eGFR and higher PWV than controls (P < 0.05). RDW were wider (P < 0.05) in male hypertensives (13.5 ± 1.1%) than male controls (13.3 ± 1.3%) but were not different between hypertensive subjects and controls in female. While, RDW were identical between controls and DM, HLP, MetS, and CKD subjects, respectively, in both sexes. Conclusion: RDW was associated with CVD risk factors and hematological measurements and may have impact on CVD in male hypertensive subjects.
Published Version
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