905 SERUM URIC ACID AS AN INDEPENDENT RISK FACTOR FOR ERECTILE DYSFUNCTION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 2011905 SERUM URIC ACID AS AN INDEPENDENT RISK FACTOR FOR ERECTILE DYSFUNCTION Gholamreza Pourmand, Sepehr Salem, Abdolrasoul Mehrsai, and Farzad Allameh Gholamreza PourmandGholamreza Pourmand Tehran, Iran More articles by this author , Sepehr SalemSepehr Salem Tehran, Iran More articles by this author , Abdolrasoul MehrsaiAbdolrasoul Mehrsai Tehran, Iran More articles by this author , and Farzad AllamehFarzad Allameh Tehran, Iran More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.796AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Serum uric acid is now beginning to be considered as a risk predictor for cardiovascular diseases. However, little is known about the effect of hyperuricemia on the risk of developing other vascular disorders, especially erectile dysfunction (ED). Our aim was to evaluate whether serum uric acid is a predicting factor for ED while adjusting for other common risk factors. METHODS During study period, 251 patients with newly diagnosed and documented ED and 252 age-matched participants without ED were enrolled in this prospective case-control study at our referral center. Serum uric acid concentration and the distribution of potential ED risk factors (age, smoking, lipid profile, hypertension, obesity and diabetes mellitus) were evaluated. Serum uric acid levels were categorized into tertiles. The 5-item International Index of Erectile Function (IIEF-5) was used to evaluate the presence and the severity of ED. The uni- and multivariate logistic regression analysis were performed to assess the effect of serum uric acid on ED severity; calculating odds ratio (OR) and 95% confidence interval (CI). Adjustments were made for potential confounding factors including obesity, hypertension, diabetes, dyslipidemia and smoking. RESULTS The mean serum uric acid in ED positive and negative groups were 6.12±1.55 mg/dl and 4.97±1.09 mg/dl, respectively (P<0.001). While analyzing unadjusted variables, a statistically significant difference was found for all variables and also serum uric acid between ED positive and negative groups. In the logistic regression analysis, the adjusted OR for diabetes, hypertension, low high-density lipoprotein, and smoking demonstrated a significant confounding effect. After adjustment for major confounders, a significant trend of increasing risk was found for serum uric acid concentration (OR: 5.95, 95% CI: 2.96–11.97; P<0.001, comparing the highest with the lowest tertiles). An increase of 1 mg/dl in serum uric acid level was associated with approximately 2-fold increase in risk of ED (OR: 2.07; 95% CI: 1.63–2.64). CONCLUSIONS This study suggests that serum uric acid could be considered as a surrogate marker which can predict the occurrence of ED. Furthermore, hyperuricemia could be regarded as an independent risk factor in addition to the established ones. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e363 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gholamreza Pourmand Tehran, Iran More articles by this author Sepehr Salem Tehran, Iran More articles by this author Abdolrasoul Mehrsai Tehran, Iran More articles by this author Farzad Allameh Tehran, Iran More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...