Abstract

1.1. In the stallion, estrogens were synthesized and sulfated in vivo by the testis.2.2. The equine testicular enzyme aromatized androgens and 19-norandrogens with similar velocity, but not 16α-hydroxytestosterone or epitestosterone in contrast to the human placental aromatase.3.3. One single enzyme was implicated in the aromatization of androstenedione, testosterone, 19-norandrostenedione and 19-nortestosterone by ETMES.4.4. During the process of androstenedione aromatization by ETMES, 19-hydroxyandrostenedione and 19-oxoandrostenedione were released and 4-hydroxyandrostenedione was a competitive inhibitor causing an additional irreversible enzyme inactivation which is what occurs with HPMES.5.5. Dihydrotestosterone was a potent competitive inhibitor of aromatase activity.

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