895P Correlating peptidylglycine alpha-amidating monooxygenase (PAM) expression with clinicopathologic variables in gastrointestinal (GI) neuroendocrine tumors (NETs)

J Sim,H Marginean,A Jirovec,M.M Vickers,E.C Marginean,T.R Asmis,B Marginean,R.A Goodwin

doi:10.1016/j.annonc.2022.07.1021

895P Correlating peptidylglycine alpha-amidating monooxygenase (PAM) expression with clinicopathologic variables in gastrointestinal (GI) neuroendocrine tumors (NETs)

J Sim, H Marginean + Show 6 more

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https://doi.org/10.1016/j.annonc.2022.07.1021

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Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Sep 1, 2022
License type: publisher-specific-oa

Affiliation: University of Ottawa, Ottawa Hospital, Ottawa Hospital Research Institute, University of British Columbia

#Peptidylglycine Alpha-amidating Monooxygenase #Peptidylglycine Alpha-amidating Monooxygenase Expression + Show 8 more

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Abstract

PAM is a protein responsible for neuroendocrine hormone maturation. Horton et al 2020, showed PAM staining intensity by immunohistochemistry (IHC) correlates with clinical and pathologic parameters in neuroendocrine neoplasms. We investigate PAM expression by IHC in patients with well-differentiated NETs exclusively of the GI tract and its correlation with clinical and pathologic variables.

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