Abstract
High intratumor heterogeneity of glioblastoma (GBM) cells and their differential reactivity to chemotherapeutic drug temozolomide (TMZ) contribute to clonal selection of TMZ-resistant clones and the disease recurrence. Numerous molecules contribute to this process; however, an involvement of glycosylated macromolecules remains under investigated. To study their potential contribution to the resistance development, we investigated different molecular and functional characteristics of various GBM cells and their association with TMZ resistance in GBM model in vitro.
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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