Abstract
Cellular infection by Adenovirus serotype 5 (Ad5) is mediated by the viral capsid fiber and penton proteins. Whereas the fiber initiates high affinity binding to cellular Coxsackievirus Adenovirus Receptor (CAR) proteins, the penton binds to secondary integrin receptors, triggering receptor-mediated endocytosis of the virus. We have previously demonstrated that recombinant soluble penton proteins can assemble with plasmid DNA and deliver a reporter gene into cultured cells in the absence of the whole virus.
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