Abstract
In this current issue of Clinical Cancer Research , Reddy et al. ([1][1]) constructed an adenoviral virotherapy agent that uses the human E2F-1 gene promoter to regulate the adenoviral E1A gene. The E2F transcription factor plays an important role in cell proliferation and is repressed by the
Highlights
Constructed an adenoviral virotherapy agent that uses the human E2F-1 gene promoter to regulate the adenoviral E1A gene
Adenoviral vectors infect both dividing and nondividing cells, have high stability in vivo and have a high capacity for gene transfer. Another beneficial attribute contributing to their employment in antitumor therapy is that adenoviruses possess a lytic life cycle that can be exploited for oncolysis
Adenoviral vectors based on the native adenoviral serotype 5 (Ad5) are the most commonly used for construction of virotherapy agents
Summary
Constructed an adenoviral virotherapy agent that uses the human E2F-1 gene promoter to regulate the adenoviral E1A gene. Because E2F regulates its own promoter, the E2F-1 promoter is preferentially active in tumor cells in which the Rb pathway is dysregulated. Most of these adenoviral virotherapy agents described above have shown remarkable preclinical results in eradicating tumors in xenograft mouse models. These experiences have established the concept that adenoviral virotherapy agents can accomplish potentially significant antitumor effects
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