843-P: Fortnight Intensive Treatment Strategy for Type 2 Diabetes

Abstract

According to ICMR IndiaB study, only 31% of Indians with type 2 diabetes (T2DM) have HbA1c ≤ 7 %. Hence, we strategize FIT (Fortnight intensive treatment) care to achieve an early Glycemic control that could effectively sustain over an extended period. In this study, individuals (N=107) with T2DM, aged >18 years with HbA1c >7% were subjected to a combination therapy of single or multiple OADs with or without insulin and short-term (14-days) insulinization. FBS (Fasting Blood sugar) and PPBS levels (Post prandial blood sugar) were measured on Day 0, 5, 14 and 90. Based on Day 0 estimates, individualized FIT care was initiated to achieve a target of FBS (100 – 130 mg/dL) and PPBS (180 – 190 mg/dL) . Treatment was intensified and optimized on Day 5 and 14, respectively. HbA1c between Day 0 and Day 90 was compared.On Day 0, mean FBS, PPBS and HbA1c values were 223.6 ± 69.2 mg/dL, 338± 68.5 and 10.1 ±1.9 %, respectively. Individuals using multiple (≥3) OADs and insulin therapy were 25% at enrolment and 75% during FIT care. After FIT care, there has been a significant reduction in FBS and PPBS (Figure 1) . By day 90, there is a significant (P<0.0001) reduction of 3.13 % in the mean HbA1c levels compared to the levels during enrolment. About 64.5% had a sustained HbA1c% of ≤7. Figure 1: Effect of FIT care across visits In T2DM, FIT care’s glycemic control as early as day 5 and day 14 is beneficial for sustained glycemic control and reduction of treatment failure. Disclosure S.Ramanarayanan: None.