Abstract
Research of chronological (intrinsic) aging in human skin and the development of potent anti-aging and rejuvenating agents are impeded by the limited availability of clinically relevant models. As current cell culture approaches cannot satisfactorily recapitulate normal human skin physiology and aging, even under 3D conditions, human full-thickness skin organ culture (hSOC) remains an excellent, but under-used alternative for pre-clinical aging research and the testing of candidate senolytics. Here, we present three distinct, complementary novel hSOC approaches to interrogating intrinsic, UV-free human skin aging.
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