Abstract
Fragmentation of dermal collagen fibrils, the major structural proteins in skin, is a prominent feature of human skin aging [1,2]. Elevated collagenase (MMP-1) is largely responsible for initiation of collagen fragmentation in aging human skin [1,3,4]. We previously reported that expression of mutant human MMP-1 (hMMP-1/V94G), which undergoes auto-activation in either young human skin in organ culture or fibroblasts cultured in 3D collagen lattices, causes collagen fibril fragmentation similar to that in aged human skin [5].
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